Best Peptides for Metabolic Syndrome in 2026
Evidence-based ranking of 1 peptides for metabolic syndrome. Ranked by clinical evidence, approval status, and effectiveness.
#1
Retatrutide
ResearchGIP/GLP-1/Glucagon Triple Receptor Agonist
The most powerful weight loss peptide in clinical development, targeting three metabolic receptors simultaneously.
Why it works for Metabolic Syndrome
Metabolic syndrome
Typical Dose
8-12 mg
Frequency
Once weekly
Half-Life
~7 days (weekly dosing enabled)
Quick Comparison
| Peptide | Class | Dose | Frequency | Approval |
|---|---|---|---|---|
| Retatrutide | GIP/GLP-1/Glucagon Triple Receptor Agonist | 8-12 mg | Once weekly | Research |
Disclaimer: Rankings are based on available clinical evidence and approval status, not personal endorsement. Always consult a licensed healthcare provider before starting any peptide. Many compounds discussed are not FDA-approved for human use.