Best Peptides for Weight Loss in 2026
Evidence-based ranking of 3 peptides for weight loss. Ranked by clinical evidence, approval status, and effectiveness.
#1
Retatrutide
ResearchGIP/GLP-1/Glucagon Triple Receptor Agonist
The most powerful weight loss peptide in clinical development, targeting three metabolic receptors simultaneously.
Why it works for Weight Loss
Weight loss
Typical Dose
8-12 mg
Frequency
Once weekly
Half-Life
~7 days (weekly dosing enabled)
#2
Semaglutide
FDA ApprovedGLP-1 Receptor Agonist
The peptide that started the weight loss revolution — FDA-approved, clinically proven, and widely accessible.
Why it works for Weight Loss
Weight loss/obesity (Wegovy)
Typical Dose
1.7-2.4 mg
Frequency
Once weekly (injectable); once daily (Rybelsus oral)
Half-Life
~7 days
#3
Tirzepatide
FDA ApprovedGIP/GLP-1 Dual Receptor Agonist
FDA-approved dual-action peptide delivering up to 22% weight loss — the gold standard of prescription weight management.
Why it works for Weight Loss
Weight loss/obesity (Zepbound)
Typical Dose
10-15 mg
Frequency
Once weekly
Half-Life
~5 days
Quick Comparison
| Peptide | Class | Dose | Frequency | Approval |
|---|---|---|---|---|
| Retatrutide | GIP/GLP-1/Glucagon Triple Receptor Agonist | 8-12 mg | Once weekly | Research |
| Semaglutide | GLP-1 Receptor Agonist | 1.7-2.4 mg | Once weekly (injectable); once daily (Rybelsus oral) | Approved |
| Tirzepatide | GIP/GLP-1 Dual Receptor Agonist | 10-15 mg | Once weekly | Approved |
Compare Head-to-Head
Disclaimer: Rankings are based on available clinical evidence and approval status, not personal endorsement. Always consult a licensed healthcare provider before starting any peptide. Many compounds discussed are not FDA-approved for human use.