Ipamorelin for Body Composition: Does It Work?
Evidence-based review of Ipamorelin's effectiveness for body composition, including mechanism of action, dosage context, clinical data, and realistic expectations.
How Ipamorelin Addresses Body Composition
By stimulating GH release, ipamorelin supports the hormonal environment for lean mass preservation and gradual fat reduction. Combined with resistance training and adequate protein, GH secretagogues can support modest improvements in body composition over 3–6 month protocols.
What Ipamorelin Is Primarily Used For
- 1.Growth hormone stimulation
- 2.Body composition improvement
- 3.Anti-aging
- 4.Sleep quality enhancement
- 5.Recovery optimization
What the Research Shows
Below is a summary of clinical evidence for Ipamorelin. Note that not all trials specifically study body composition as an endpoint.
Ipamorelin reliably stimulates GH secretion in a dose-dependent manner with high selectivity, producing minimal cortisol or prolactin elevations compared to GHRP-6 or GHRP-2.
Ipamorelin accelerated return of gut motility compared to placebo, suggesting utility beyond body composition.
Realistic Expectations
Dosage Context for Body Composition
Typical range: 100–500 mcg, 1–3 times daily (often before bed and/or around workouts)
Commonly dosed at 200–300mcg per injection, 1–3 times daily. Best taken on an empty stomach to maximize GH pulse. Frequently combined with CJC-1295 or GHRH peptides for synergistic effect.
Doses for body composition may vary from general guidelines. Consult a healthcare provider for condition-specific dosing.
Legal Status & Access
Research chemical in the US. Not FDA approved. Available through peptide research suppliers.