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Semaglutide Dosage Guide: How Much to Take

Complete dosage information for Semaglutide including starting dose, maintenance dose, titration schedule, and administration guidance.

Dosage at a Glance

Starting Dose

0.25

Typical Dose

1.7-2.4

Max Studied Dose

2.4

Frequency: Once weekly (injectable); once daily (Rybelsus oral)

Dosing Notes

For Wegovy: Start at 0.25mg weekly, titrate by 0.25mg every 4 weeks up to 2.4mg maintenance dose. For Ozempic: Max dose is 2mg. Oral Rybelsus dose is 3mg daily titrating to 14mg.

Titration Schedule

Gradual titration reduces GI side effects. Follow this schedule, adjusting based on tolerability.

Week	Dose	Notes
Week 1	0.25mg	Starting dose — assess tolerability
Week 5	0.5mg	Increase if tolerated
Week 9	1mg	Increase if tolerated
Week 13	1.7mg	Increase if tolerated
Week 17	2.4mg	Maintenance dose

Administration Routes

✓Subcutaneous injection (abdomen, thigh, upper arm)
✓Oral tablet (Rybelsus)

What to Do If You Miss a Dose

General guidance: If you miss a dose, take it as soon as you remember — unless it's almost time for your next dose. Never double up. For weekly peptides, a 1–2 day delay is generally acceptable without restarting titration.

How to Reconstitute Semaglutide

If you have lyophilized (freeze-dried) Semaglutide powder, it must be reconstituted with bacteriostatic water (BAC water) before use. Here is the standard reconstitution process:

Gather supplies

Lyophilized peptide vial, bacteriostatic water (BAC water), insulin syringe, alcohol swabs

Clean surfaces

Wipe the rubber stoppers of both vials with alcohol swabs and allow to air dry

Draw BAC water

Draw the desired volume of BAC water into an insulin syringe

Add BAC water slowly

Insert needle into the peptide vial at an angle; let BAC water run down the inside wall — do NOT inject directly onto the powder

Swirl gently

Gently swirl (do NOT shake) until the powder fully dissolves — the solution should be clear

Store correctly

Refrigerate immediately at 2–8°C (36–46°F). Use within 28 days.

BAC Water Volume Reference

The amount of BAC water you add determines the concentration per unit (IU or tick) on your syringe. Common configurations:

Vial Size	BAC Water Added	Concentration	Volume per mg
5mg	1mL	5mg/mL	0.20mL per 1mg
5mg	2mL	2.5mg/mL	0.40mL per 1mg
10mg	1mL	10mg/mL	0.10mL per 1mg
10mg	2mL	5mg/mL	0.20mL per 1mg

Using a 100-unit (1mL) insulin syringe: each 10 tick marks = 0.1mL. Adjust your draw based on the concentration above.

Storage & Shelf Life

Lyophilized (dry powder)

Temperature: 2–8°C refrigerated

Shelf life: 12–24 months

Can withstand room temp for shipping (few days)

Reconstituted (liquid)

Temperature: 2–8°C refrigerated only

Shelf life: 28 days

Never freeze reconstituted peptide — degrades quickly

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Medical Disclaimer: Dosage information is based on available research and clinical trial protocols. This is not medical advice. Consult a licensed healthcare provider before using any peptide.