BPC-157: Overview, Dosage, Side Effects & Research
A synthetic peptide derived from gastric juice protein, studied for accelerating healing of tendons, muscles, and gut tissue.
Also known as: Body Protection Compound 157, PL 14736
What is BPC-157?
BPC-157 is a 15-amino acid peptide fragment derived from a body protection compound found in human gastric juice. Its proposed mechanisms include upregulating growth hormone receptors in tendon fibroblasts, promoting angiogenesis (new blood vessel formation), modulating nitric oxide signaling, and reducing inflammatory cytokines. Animal studies suggest it accelerates healing of tendons, ligaments, muscles, and gut mucosa.
Dosage Overview
| Level | Dose |
|---|---|
| Starting / Low | 200 mcg |
| Typical / Maintenance | 250-500 mcg |
| Maximum (studied) | 1000 mcg |
Most research protocols use 250–500mcg per injection, once or twice daily. Oral dosing also used for gut-specific effects (same dose range). Injectable BPC-157 should be reconstituted with bacteriostatic water.
Full dosage guide with titration schedule →Side Effects
| Side Effect | Frequency |
|---|---|
| Nausea (oral dosing) | uncommon |
| Dizziness | uncommon |
| Injection site discomfort | common |
| Fatigue | uncommon |
Clinical Research
Multiple rodent studies show significantly accelerated tendon-to-bone healing, reduced inflammation, and improved functional outcomes with BPC-157 vs controls.
Limited human data exists. Topical rectal application showed some benefit in a small Crohn's disease trial. No completed Phase 3 trials.
Best Used For
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Frequently Asked Questions
Is BPC-157 FDA approved?
No. BPC-157 is not FDA approved for any indication. It is classified as a research chemical, meaning it is legally sold for laboratory research but not for human use. It is not available as a prescription medication in the US.
What is BPC-157 used for?
Athletes and biohackers primarily use BPC-157 for injury recovery — specifically tendons, ligaments, and muscle tears. It is also used for gut healing (leaky gut, Crohn's symptoms). The evidence base is primarily animal studies; human clinical data is limited.
How do you take BPC-157?
BPC-157 can be taken subcutaneously (under the skin), intramuscularly (in the muscle), or orally. For localized healing (e.g., a torn tendon), injection near the injury site is commonly used. For gut-related issues, oral dosing is preferred.
Is BPC-157 safe?
Animal studies show a strong safety profile with no significant toxicity at therapeutic doses. However, long-term human safety data is limited. As with any research chemical, use carries unknown risks.
What is the best BPC-157 stack for injury recovery?
The most commonly discussed stack is BPC-157 with TB-500 (thymosin beta-4). These peptides work through complementary mechanisms: BPC-157 drives angiogenesis and GH receptor upregulation at injury sites, while TB-500 promotes cell migration and new tissue fiber formation. Animal data suggests synergistic healing effects.
How long does BPC-157 take to work?
Anecdotal reports suggest users notice reduced pain and improved mobility within 1–3 weeks. Animal studies show accelerated healing timelines compared to untreated controls. There are no controlled human trials defining a precise timeline. Most protocols run 4–12 weeks depending on injury severity.
What is the correct dosage for BPC-157?
The most common research dosing is 200–500 mcg per day, either as a single injection or split into two doses. For localized injuries, injection near (but not directly into) the injured area is typical. These doses are based on animal studies scaled to human weight — there is no established human clinical dosage.
Does BPC-157 cause cancer?
BPC-157 promotes angiogenesis (new blood vessel formation), which is a theoretical concern because tumors also rely on angiogenesis for growth. Animal studies have not shown tumor promotion from BPC-157, but researchers with active cancer or a personal cancer history should exercise caution and consult an oncologist before use.
Can BPC-157 heal tendon injuries?
Animal studies — primarily in rats — show dramatically accelerated tendon healing following surgical transection when treated with BPC-157. Healing timelines are reduced by 50–75% in some studies. Mechanisms include upregulation of GH receptors in tendon fibroblasts and improved vascularization. Human trial data does not exist.
Where can I buy BPC-157?
BPC-157 is sold by peptide research suppliers in the US and internationally. Look for suppliers with third-party COA documentation (HPLC purity ≥98%, mass spectrometry verification). Avoid suppliers with no quality documentation. It is legal to purchase for research use in the US; it is not legal to sell or market for human use.
Where to Source BPC-157
Sourcing guidance, supplier vetting criteria, and price benchmarks.
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